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Case Study of Physiotherapy Treatment of a Patient with Antisynthetase Syndrome
Alkhatib, Amineh ; Vomáčková, Helena (advisor) ; Mikulášová, Markéta (referee)
Author: Amineh Alkhatib Title of thesis: Case Study of Physiotherapy Treatment of a Patient with Antisynthetase Syndrome. Work placement: Institute of Rheumatology Prague Objectives: The aim of the thesis was to investigate the various physiotherapeutic techniques in improving the physical state of a 36-year-old, male patient with Interstitial lung disease related to Antisynthetase syndrome with the presence of AntiEJ, AntiRO52 and, AntiRO60 antibodies. Methods: PIR, DNS, soft tissue techniques, joint mobilization, physical exercises, IMT threshold, sensomotoric exercises. Results: Improvement in breathing capacity and breathing pattern, improvement in posture, improved mobility of soft tissues. Conclusion: This study was divided into 2 parts, the general part, which discusses the anatomy of the respiratory system and the nature of the disease, and the special part, which represents the course of the treatment and its effect on improving the general well-being of the patient. During this study, the application of physiotherapeutic methods has proved the possibility of improving the clinical symptoms for patients with Antisynthetase syndrome. Applying soft tissue techniques along with PIR and other physiotherapeutic techniques, had a great impact in improving the patient's posture, breathing...
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BAFF (B-cell Activating Factor of the TNF Family) in patients with idiopathic inflammatory myopathieswith respect to autoantibody profile.
Kryštůfková, Olga ; Vencovský, Jiří (advisor) ; Tlaskalová - Hogenová, Helena (referee) ; Blažíčková, Stanislava (referee)
The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of chronic muscle diseases with frequent extramuscular organ involvement that contributes to serious prognosis. The presence of autoantibodies and composition of muscle infiltrates both support autoimmune nature of the disease and pathogenic role of B lymphocytes. Besides the traditional diagnostic subgroups, autoantibody characterised phenotype subsets have been identified with presumed similar pathogenic mechanisms. The best known is the antisynthetase syndrome which is characterised by presence of myositis, antisynthetase autoantibodies (with anti-Jo-1 being the most frequent), interstitial lung disease and other extramuscular manifestations. BAFF (B cell-Activating Factor of the TNF Family) is a key factor in B cell homeostasis modulation. In high levels, it allows survival of autoreactive B cell clones and thus participates in the pathogenesis of autoimmune diseases. Its expression is induced by type I interferons (IFN-1). The aim of the PhD thesis was to explore the role of BAFF in pathogenesis of IIMs by analysis of its serum levels, the receptors for BAFF in muscle tissue, their associations to IFN-1 and expression of BAFF gene mRNA transcription variants in peripheral blood cells. Further aspect was to study a possible...
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